کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2410958 | 1103292 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mucosal vaccination with an attenuated maedi–visna virus clone
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Four sheep were infected intratracheally with an attenuated molecular clone of maedi–visna virus (MVV). All four became infected. Ten months later these sheep were challenged intratracheally with a genetically similar but pathogenic clone of MVV. Four unvaccinated sheep were infected simultaneously. All sheep became infected by the challenge virus. The vaccinated sheep were not protected against superinfection with the challenge clone. However, virus was isolated more frequently from the blood of the unvaccinated controls than of the vaccinated animals and ten times more frequently from lungs of unvaccinated sheep than from lungs of vaccinated sheep at sacrifice, indicating partial protection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issue 24, 2 May 2005, Pages 3223–3228
Journal: Vaccine - Volume 23, Issue 24, 2 May 2005, Pages 3223–3228
نویسندگان
Gudmundur Pétursson, Sigrídur Matthíasdóttir, Vilhjálmur Svansson, Valgerdur Andrésdóttir, Gudmundur Georgsson, Agnes H. Martin, Gudrún Agnarsdóttir, Eygló Gísladóttir, Steinunn Árnadóttir, Svava Högnadóttir, Stefán Ragnar Jónsson, Ólafur S. Andrésson,