کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2411031 1551798 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antigenic complementarity between HIV and other AIDS-associated infections results in idiotype–antiidiotype antibody complexes that cross react with lymphocyte proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Antigenic complementarity between HIV and other AIDS-associated infections results in idiotype–antiidiotype antibody complexes that cross react with lymphocyte proteins
چکیده انگلیسی

HIV proteins mimic HLA proteins, and the proteins of cofactor infections (cytomegalovirus, hepatitis viruses, mycobacteria, mycoplasmas) mimic CD4 proteins, making some HIV antigens molecularly complementary to cofactor antigens. Antibodies to HIV and its cofactors should therefore act like idiotype–antiidiotype pairs. Over 2000 combinations of antibodies were tested for such complementarity using modified forms of Ouchterlony immunodiffusion and ELISA. HIV antibodies do precipitate some antibodies against cofactor infections including CMV, HBV, mycobacteria and mycoplasmas. These antibodies also mimic antibodies against HLA and CD4 proteins. Thus, some combinations of HIV with cofactor infections may induce lymphocytotoxic antibodies (LCTA), a risk that must be addressed in vaccine development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issues 17–18, 18 March 2005, Pages 2160–2163
نویسندگان
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