کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2411043 | 1551798 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Validation of the serum bactericidal assay for measurement of functional antibodies against group B meningococci associated with vaccine trials
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Validation of the serum bactericidal assay for measurement of functional antibodies against group B meningococci associated with vaccine trials Validation of the serum bactericidal assay for measurement of functional antibodies against group B meningococci associated with vaccine trials](/preview/png/2411043.png)
چکیده انگلیسی
Provisional licensure of the trial vaccine, MeNZB™, required demonstration of immune responses in vaccines, as measured by a validated Serum Bactericidal Assay (SBA). Reported are the investigations undertaken to define test parameters, lower limits of quantitation and measurement of SBA reproducibility. Results helped to formulate the operating procedure for the measurement of serum bactericidal antibodies during six age-group MeNZB™ vaccine trials. The lower limit of quantitation was determined as a titre of 4. A four-fold rise in antibody (sero-conversion) from a pre-vaccination titre of 2 (<4) required a minimum post-vaccination titre of 8, a more stringent measurement than has been used in other published studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issues 17–18, 18 March 2005, Pages 2218–2221
Journal: Vaccine - Volume 23, Issues 17–18, 18 March 2005, Pages 2218–2221
نویسندگان
D. Martin, L. McCallum, A. Glennie, N. Ruijne, P. Blatchford, J. O’Hallahan, P. Oster,