کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2411051 | 1551798 | 2005 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Peptide-based candidate vaccine against respiratory syncytial virus Peptide-based candidate vaccine against respiratory syncytial virus](/preview/png/2411051.png)
We engineered a 21-mer peptide representing amino acids 170–190 of the respiratory syncytial virus (RSV) G protein as a fusion with the Alfalfa mosaic virus (AlMV) coat protein (CP), produced recombinant AlMV particles presenting this peptide (VMR-RSV) on their surfaces and tested the immunogenicity in vitro in human dendritic cells and in vivo in non-human primates. Significant pathogen-specific immune responses were generated in both systems: (i) human dendritic cells armed with VMR-RSV generated vigorous CD4+ and CD8+ T cell responses; (ii) non-human primates that received these particles responded by mounting strong cellular and humoral immune responses. This approach may validate the use of a novel RSV vaccine delivery vehicle in humans.
Journal: Vaccine - Volume 23, Issues 17–18, 18 March 2005, Pages 2261–2265