کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2411059 | 1551798 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides](/preview/png/2411059.png)
چکیده انگلیسی
We have investigated the lipid polylysine core peptide (LCP) system as a self-adjuvanting group A streptococcal (GAS) vaccine delivery approach. LCP constructs were synthesised incorporating peptides from the M protein conserved carboxy terminal C-repeat region, the amino terminal type-specific region and from both of these regions. Immunisation with the constructs without adjuvant led to the induction of peptide-specific serum IgG antibody responses, heterologous opsonic antibodies, and complete protection from GAS infection. These data indicate that protective immunity to GAS infection can be evoked using the self-adjuvanting LCP system, and point to the potential application of this system in human mucosal GAS vaccine development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 23, Issues 17–18, 18 March 2005, Pages 2298–2303
Journal: Vaccine - Volume 23, Issues 17–18, 18 March 2005, Pages 2298–2303
نویسندگان
Colleen Olive, K. Hsien, A. Horváth, T. Clair, P. Yarwood, I. Toth, M.F. Good,