کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2421771 | 1552855 | 2014 | 5 صفحه PDF | دانلود رایگان |
• The combination of lysozyme and phage show better activity than phage alone.
• The use of phages with lysozyme is a useful strategy to reduce pathogenic bacteria.
• Namely when less effective phages are available.
Phage therapy gained increased attention as an alternative to antibiotics in order to control bacterial diseases and prevent the spreading of multidrug-resistant bacteria in aquaculture. In this study, the addition of a lytic enzyme (lysozyme) during phage therapy was evaluated for the first time to control Vibrio infection. Three phages of Vibrio parahaemolyticus (VP-1, VP-2 and VP-3) were used. The results indicate that the combination of lysozyme and phage showed better activity in comparison to the activity of the phage alone. VP-1 and VP-2 phages in the presence of lysozyme were more effective in reducing bacterial concentration (reductions of 4.0 log) than the VP-3 phage (which was the most efficient against Vibrio). The application of phages along with lysozyme can be a very useful strategy to eliminate or reduce fish pathogenic bacteria in aquaculture, namely when less effective phages are available.
Journal: Aquaculture - Volume 432, 20 August 2014, Pages 125–129