کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2436191 | 1107287 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis](/preview/png/2436191.png)
The rat lugworm Angiostrongylus cantonensis can cause eosinophilic meningitis. The purpose of this study was to determine whether matrix metalloproteinase (MMP)-12 and its substrate elastin participate in this inflammatory response. We showed that the MMP-12/tissue inhibitor of metalloproteinase-1 ratio was significantly increased in the CSF of A. cantonensis-infected mice from day 10 p.i., and reached high levels on days 20 and 25 p.i. MMP-12 production was correlated with elastin degradation, eosinophil count, blood–CSF barrier permeability and pathological changes in the subarachnoid space. Also, MMP-12 might contribute to elastin degradation in the meningeal vessel of the subarachnoid space. Simultaneous administration of albendazole and doxycycline significantly reduced the levels of MMP-12, elastin and Evans blue in mice with meningitis. These results imply that MMP-12 contributes to the elastin degradation that occurs in angiostrongyliasis meningitis, and doxycycline can reverse related inflammatory events by inhibition of MMP-12.
Figure optionsDownload high-quality image (43 K)Download as PowerPoint slideHighlights
► Matrix metalloproteinase (MMP)-12 was significantly increased in the CSF of Angiostrongylus cantonensis-infected mice.
► MMP-12 production was correlated with elastin degradation, eosinophil count and blood–CSF barrier permeability.
► Albendazole and doxycycline co-therapy was significantly reduced the level of MMP-12, elastin and Evans blue dye.
► MMP-12 contributes to the elastin degradation that occurs in angiostrongyliasis meningitis.
Journal: International Journal for Parasitology - Volume 41, Issue 11, September 2011, Pages 1175–1183