کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2471016 | 1555748 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxoplasma gondii: Prototype immunization of lambs against formation of muscle and brain cysts
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Nine lambs were immunized with 106 oocysts of the relatively avirulent ME-49 strain of Toxoplasma gondii, and were challenged 45 days later with 4 × 106 oocysts of the M3 strain of this parasite. Less than 5 tissue cysts of the M3 strain formed per 8 g of muscle – if any – judging from a bioassay in mice in which all mice survived. In contrast, mortality occurred in mice fed muscle specimens from 4 lambs that had not been immunized with ME-49 prior to challenge with the M3 strain. This finding suggests the possibility of creating a vaccine for lambs that could diminish or abolish lamb and mutton as sources of human infection with T. gondii, and which could also prevent toxoplasmosis abortion in sheep.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Parasitology - Volume 166, Issues 1–2, 3 December 2009, Pages 15–20
Journal: Veterinary Parasitology - Volume 166, Issues 1–2, 3 December 2009, Pages 15–20
نویسندگان
J. Falcón, A. Freyre,