Injected nanocrystals for targeted drug delivery

Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs. Nanocrystals in the blood stream can be recognized and sequestered as exogenous materials by mononuclear phagocytic system (MPS) cells, leading to passive accumulation in MPS-rich organs, such as liver, spleen and lung. Particle size, morphology and surface modification affect the biodistribution of nanocrystals. Ligand conjugation and stimuli-responsive polymers can also be used to target nanocrystals to specific pathogenic sites. In this review, the progress on injected nanocrystals for targeted drug delivery is discussed following a brief introduction to nanocrystal preparation methods, i.e., top-down and bottom-up technologies.

Nanocrystals can be prepared by either top-down or bottom-up technologies. Injected nanocrystals can be passively accumulated in liver, spleen and lung due to sequestering and transportation by mononuclear phagocytic system cells. Ligand conjugation and stimuli-responsive polymer can be used to target nanocrystals to specific pathogenic sites.Figure optionsDownload as PowerPoint slide