کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2474663 | 1113155 | 2012 | 8 صفحه PDF | دانلود رایگان |
This study aimed to investigate the ability of chelerythrine chloride (CHE), the main active ingredient of Macleaya cordata, to induce apoptosis in human gastric cancer BGC-823 cells. The results demonstrate that CHE inhibits cell proliferation in a time- and dose-dependent manner with accompanying S phase arrest. It also induces apoptosis by a mechanism involving a reduction in the mitochondrial membrane potential, the release of cytochrome c, activation of caspase 3 and cleavage of poly-ADP-ribose polymerase. In addition, CHE-induced apoptosis is accompanied by down-regulation of Bcl-xl and Bcl-2 proteins with no change in the levels of Bax proteins. Taken together, the results support the development of CHE as a potentially useful anticancer drug for the treatment of gastric cancer.
Chelerythrine chloride (CHE) induces human gastric cancer BGC-823 cells apoptosis by a mechanism involving a reduction in the mitochondrial membrane potential, the release of cytochrome c, activation of caspase 3 and cleavage of poly-ADP-ribose polymerase, accompanied by down-regulation of Bcl-xl and Bcl-2 proteins with no change in the levels of Bax proteins. Figure optionsDownload as PowerPoint slide
Journal: Acta Pharmaceutica Sinica B - Volume 2, Issue 5, October 2012, Pages 464–471