کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474774 1113163 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects and mechanisms of berberine in diabetes treatment
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Effects and mechanisms of berberine in diabetes treatment
چکیده انگلیسی

Berberine from Rhizoma Coptidis is an oral hypoglycemic agent with anti-dyslipidemia and anti-obesity activities. Its metabolic activity of regulating blood glucose and lipids has been widely studied and evidenced in patients and various animal models. Berberine is known as an AMP-activated protein kinase (AMPK) activator. Its insulin-independent hypoglycemic effect is related to inhibition of mitochondrial function, stimulation of glycolysis and activation of AMPK pathway. Additionally, berberine may also act as an α-glucosidase inhibitor. In the newly-diagnosed type 2 diabetic patients, berberine is able to lower blood insulin level via enhancing insulin sensitivity. However, in patients with poor β-cell function, berberine may improve insulin secretion via resuscitating exhausted islets. Furthermore, berberine may have extra beneficial effects on diabetic cardiovascular complications due to its cholesterol-lowering, anti-arrhythmias and nitric oxide (NO) inducing properties. The antioxidant and aldose reductase inhibitory activities of berberine may be useful in alleviating diabetic nephropathy. Although evidence from animal and human studies consistently supports the therapeutic activities of berberine, large-scale multicenter trials are still necessary to evaluate the efficacy of berberine on diabetes and its related complications.

The insulin-independent hypoglycemic effect of berberine is related to inhibition of mitochondrial function, stimulation of glycolysis and activation of AMPK pathway. Additionally, the antioxidant and aldose reductase inhibitory activities of berberine may be useful in alleviating diabetic nephropathy.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 2, Issue 4, August 2012, Pages 327–334
نویسندگان
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