کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474866 1113169 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advances in Mycobacterium siderophore-based drug discovery
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Advances in Mycobacterium siderophore-based drug discovery
چکیده انگلیسی

Tuberculosis remains a public health threat of global proportions. Iron is a scarce resource indispensable to both host and pathogen during infection with Mycobacterium tuberculosis, the causative agent of tuberculosis. Siderophores are critical molecules for iron acquisition under iron-limiting conditions and, as a very efficient pathogen, M. tuberculosis has evolved elaborate siderophores knowledge of which is being intensively translated into clinical practice. This paper summarizes the structures, types and physiological functions of Mycobacterium siderophores with emphasis on siderophore-inspired design of drugs and drug delivery vehicles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 1, Issue 1, June 2011, Pages 8–13
نویسندگان
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