کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484469 | 1114311 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors](/preview/png/2484469.png)
چکیده انگلیسی
We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1 (PEPT1, SLC15A1) in rats. After oral administration of glucose or mannitol to rats, CEX was administered together with a second dose of glucose or mannitol. Western blot analysis indicated that expression of PEPT1 in rat jejunum membrane was decreased by glucose, compared to mannitol. Furthermore, the maximum plasma concentration (Cmax) of orally administered CEX was reduced by glucose compared to mannitol. The effect of glucose was diminished by nifedipine, a l-type Ca2+ channel blocker. We also found that Cmax of orally administered CEX was reduced by treatment with l-glutamic acid, compared to d-glutamic acid. Thus, excessive intake of glucose and l-glutamic acid may impair oral absorption of PEPT1 substrates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 1, January 2016, Pages 339-342
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 1, January 2016, Pages 339-342
نویسندگان
Hiroshi Arakawa, Taichi Ohmachi, Kiko Ichiba, Hiroki Kamioka, Takumi Tomono, Masahiko Kanagawa, Yoko Idota, Yasuko Hatano, Kentaro Yano, Kaori Morimoto, Takuo Ogihara,