کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2484570 1114318 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
One-Step Self-Assembling Method to Prepare Dual-Functional Transferrin Nanoparticles for Antitumor Drug Delivery
ترجمه فارسی عنوان
یک روش تک مرحله ای خودآموز برای آماده سازی نانوذرات انتقال دهنده دوطرفه برای تحویل داروهای ضد تومور
کلمات کلیدی
فناوری نانو، سیستم های تحویل دارو، پروتئین تاشو / بازخوانی پروتئین ها، خودآموزی، انحلال پذیری، تحویل هدفمند مواد مخدر،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
Protein-based nanoparticles hold great promise in both preclinical and clinical practices due to their high biocompatibility and biodegradability. However, the complicated preparations often denature proteins, which subsequently diminish their bioactivity. To overcome these drawbacks, we developed a one-step self-assembling method for preparing protein-based nanoparticles. Transferrin (Tf), a targeting protein, was mixed with 2-mercaptoethanol to break disulfide bonds. Using this method, Tf-PTX-NPs (paclitaxel-loaded Tf nanoparticles) could be readily obtained. Tf-PTX-NPs were round and their diameter could be controlled in the range of 5-200 nm. The bioactivity of Tf to its receptor after forming nanoparticles was also confirmed in vitro. Tf-PTX-NPs also could inhibit the tumor growth to some extent in a mice tumor xenograft model. Therefore, using this self-assembling method, we fabricated this antitumor Tf-based nanoparticle, in which Tf acted as both the targeting moiety and drug carrier.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 3, March 2016, Pages 1269-1276
نویسندگان
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