کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484572 | 1114318 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Sustainable Release of Vancomycin and Its Degradation Products From Nanostructured Collagen/Hydroxyapatite Composite Layers
ترجمه فارسی عنوان
انتشار پایدار ونکوماسین و محصولات تجزیه آن از لاکتات کلاژن / هیدروکسی آپاتیت نانوساختار
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کلمات کلیدی
Controlled release - انتشار کنترل شدهDrug delivery systems - سیستم های تحویل داروPolymeric drug delivery systems - سیستم های تحویل دارویی پلیمریAnti-infectives - ضد عفونتPharmacokinetics - فارماکوکینتیکDegradation products - محصولات تخریب شدهNanoparticles - نانوذراتCoating - پوششHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Infections of the musculoskeletal system present a serious problem with regard to the field of orthopedic and trauma medicine. The aim of the experiment described in this study was to develop a resorbable nanostructured composite layer with the controlled elution of antibiotics. The layer is composed of collagen, hydroxyapatite nanoparticles, and vancomycin hydrochloride (10 wt%). The stability of the collagen was enhanced by means of cross-linking. Four cross-linking agents were studied, namely an ethanol solution, a phosphate buffer solution of N-(3-dimethylaminopropyl)-Nâ²-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide, genipin, and nordihydroguaiaretic acid. High performance liquid chromatography was used so as to characterize the in vitro release rates of the vancomycin and its crystalline degradation antibiotically inactive products over a 21-day period. The maximum concentration of the released active form of vancomycin (approximately 265 mg/L) exceeded the minimum inhibitory concentration up to an order of 17 times without triggering the burst releasing effect. At the end of the experiment, the minimum inhibitory concentration was exceeded by up to 6 times (approximately 100 mg/L). It was determined that the modification of collagen with hydroxyapatite nanoparticles does not negatively influence the sustainable release of vancomycin. The balance of vancomycin and its degradation products was observed after 14 days of incubation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 3, March 2016, Pages 1288-1294
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 3, March 2016, Pages 1288-1294
نویسندگان
TomáÅ¡ Suchý, Monika Å upová, Eva Klapková, LukáÅ¡ Horný, Å árka Rýglová, Margit Žaloudková, Martin Braun, ZbynÄk Sucharda, Rastislav Ballay, Jan Veselý, Hynek Chlup, FrantiÅ¡ek Denk,