کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2484702 1114325 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studies on Solvatomorphism of Betulinic Acid
ترجمه فارسی عنوان
مطالعات روی سولاتومورفیسم بتولینیک اسید
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

ABSTRACTFive solvates of betulinic acid with dimethyl sulfoxide (I), methanol (II), ethanol (III), isopropyl alcohol (IV), and 2‐butanol (V) have been described in this work. Methods of X‐ray crystallography, thermal analysis, and Fourier transform infrared spectroscopy were introduced for solvatomorphic identifications and characterizations. The orientation of isopropenyl and carboxylic groups might differ because of single‐bonding rotations. The incorporation of solvents resulted in changes of the crystal symmetry, intermolecular arrangements, stoichiometry, hydrogen bonding interactions, and so on. Adducted solvents contributed most to the stability of crystal lattices and led to the formation of crystalline forms. Solvates II–V with their single‐crystal structures determined have been reported for the first time. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2696–2703, 2014

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 9, September 2014, Pages 2696–2703
نویسندگان
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