کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484888 | 1114339 | 2012 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of water uptake and mechanical properties of blended polymer films for preparing gasâgenerated multipleâunit floating drug delivery systems
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
Among various strategies of gastroretentive drug delivery systems (DDSs) developed to prolong the gastric residence time and to increase the overall bioavailability, effervescent multipleâunit floating DDSs (muFDDSs) were studied here. These systems consist of drug (losartan)â and effervescent (sodium bicarbonate)âcontaining pellets coated with a blended polymeric membrane, which was a mixture of gastrointestinal tract (GIT)âsoluble and GITâinsoluble polymers. The addition of GITâsoluble polymers, such as hydroxypropyl methylcellulose, polyethylene glycol (PEG) 6000, PEG 600, and Kollicoat® IR, greatly increased the water uptake ability of the GITâinsoluble polymers (Eudragit® NE, RS, and RL; Surelease®; and Kollicoat® SR) and caused them to immediately initiate the effervescent reaction and float, but the hydrated films should also be impermeable to the generated CO2 to maintain floatation and sufficiently flexible to withstand the pressure of carbon dioxide to avoid rupturing. The study demonstrated that the water uptake ability and mechanical properties could be applied as screening tools during the development of effervescent muFDDSs. The optimized system of SRT(5)P600(5) (i.e., a mixture of 5% Kollicoat® SR and 5% PEG 600) with a 20% coating level began to completely float within 15 min and maintained its buoyancy over a period of 12 h with a sustainedârelease effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 10, October 2012, Pages 3811-3822
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 10, October 2012, Pages 3811-3822
نویسندگان
YingâChen Chen, LinâWen Lee, HsiuâO Ho, Chen Sha, MingâThau Sheu,