کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484984 | 1114342 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Photostability of Crystalline Versus Amorphous Nifedipine and Nimodipine
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Photostability of Crystalline Versus Amorphous Nifedipine and Nimodipine Photostability of Crystalline Versus Amorphous Nifedipine and Nimodipine](/preview/png/2484984.png)
چکیده انگلیسی
True solid-state photostability of the drugs nifedipine and nimodipine was investigated during exposure to UV-visible radiation. Photostability was studied on a small scale as thin films of approximately 1Â mg drug, which contained either amorphous or re-crystallised stable phases. High-performance liquid chromatography analysis revealed a greater rate and extent of decomposition for the amorphous phases. Photoexposed amorphous nifedipine exhibited approximately 1.8-fold larger first-order decomposition rate constant (k) relative to its crystalline phase. The increase in k was more significant for photoexposed amorphous nimodipine at approximately sixfold relative to its crystalline phase. Photodecomposition in scaled-up samples of the stable crystalline phases for both drugs was monitored with X-ray diffraction in Bragg-Brentano geometry. The similarities in the calculated photodecomposition extents to results from small scale validated the specificity of the X-ray analysis technique to the photodecomposition region. The considerably faster decomposition rates in small-scale studies were attributed to a maximised surface area (A) for quantity (m0) of exposed drug. Kinetic interpretations of true solid-state stability should consider the sample solid dimensions in terms of the direct exposed A and m0 in the photodecomposition region, that is, outer layers in solid.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 6, June 2013, Pages 1883-1894
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 6, June 2013, Pages 1883-1894
نویسندگان
Driekus Grooff, Farzaana Francis, Melgardt M. De Villiers, Ernst Ferg,