کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485210 | 1114348 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of ultrasound extrudated and cut citric acid/paracetamol blends
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of ultrasound extrudated and cut citric acid/paracetamol blends Characterization of ultrasound extrudated and cut citric acid/paracetamol blends](/preview/png/2485210.png)
چکیده انگلیسی
The purpose of the present work was to study the effect of ultrasound extrusion and cutting on the physical stability of a viscous and sticky supercooled melt containing (50/50, w/w, %) citric acid anhydrate and paracetamol. Samples were extrudated at temperatures of 50, 60, and 70°C using power levels of 0, 50, 100, and 150 W. Similarly, extrudates prepared at 60°C were cut at temperatures ranging from 25-60°C with an ultrasound knife in the range 0, 50, and 100 W. The characterization methods used were: high performance liquid chromatography, differential scanning calorimetry, Karl Fischer titration, X-ray powder diffraction, Fourier transform infrared microscopy, optical- and stereomicroscopy. There was no physical difference in extrudates or cut surfaces whether processed with or without ultrasound. During 1-year aging time in dry conditions, all the samples were observed to crystallize slowly and ultrasound processing did not enhance the crystallization. Ultrasound thus holds some promise for processing of viscous and sticky pharmaceuticals, provided the material is physically stable enough to withstand mechanical and thermal stress. Processing of sticky and viscous material would be difficult without ultrasound with the methods currently used in pharmaceutical industry. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:2140-2148, 2009
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 6, June 2009, Pages 2140-2148
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 6, June 2009, Pages 2140-2148
نویسندگان
P. Hoppu, J. Virpioja, S. Schantz, A.M. Juppo,