کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485324 | 1114352 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polyurethane Intravaginal Ring for Controlled Delivery of Dapivirine, a Nonnucleoside Reverse Transcriptase Inhibitor of HIV-1
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کلمات کلیدی
DapivirineControlled delivery - تحویل کنترل شدهPolymeric drug carrier - حامل مواد مخدر پلیمریIntravaginal ring - حلقه داخل وریدیRelease kinetics - سینتیک را آزاد کنیدFormulation vehicle - فرمولبندی خودروNonnucleoside reverse transcriptase inhibitor - مهار کننده ترانس کریتاز معکوس غیر انسانیDiffusion - واپخش یا انتشار
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Women-controlled methods for prevention of male-to-female sexual transmission of HIV-1 are urgently needed. Providing inhibitory concentrations of HIV-1 reverse transcriptase inhibitors to impede the replication of the virus in the female genital tissue offers a mechanism for prophylaxis of HIV-1. To this end, an intravaginal ring device that can provide long duration delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1, was developed utilizing a medical-grade polyether urethane. Monolithic intravaginal rings were fabricated and sustained release with cumulative flux linear with time was demonstrated under sink conditions for a period of 30 days. The release rate was directly proportional to the amount of drug loaded. Another release study conducted for a week utilizing liposome dispersions as sink conditions, to mimic the partitioning of dapivirine into vaginal tissue, also demonstrated release rates constant with time. These results qualify polyether urethanes for development of intravaginal rings for sustained delivery of microbicidal agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 10, October 2008, Pages 4228-4239
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 10, October 2008, Pages 4228-4239
نویسندگان
Kavita M. Gupta, Serena M. Pearce, Azadeh E. Poursaid, Hyder A. Aliyar, Patrick A. Tresco, Mark A. Mitchnik, Patrick F. Kiser,