کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2485460 1114355 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biocompatible Microemulsion Modifies the Pharmacokinetic Profile and Cardiotoxicity of Doxorubicin
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Biocompatible Microemulsion Modifies the Pharmacokinetic Profile and Cardiotoxicity of Doxorubicin
چکیده انگلیسی
Doxorubicin (DOX) is an anthracycline antibiotic with a broad antitumor spectrum. However, the clinical use of DOX is limited because of its cardiotoxicity, a dose‐dependent effect. Colloidal drug delivery systems, such as microemulsions (MEs), allow the incorporation of drugs, modifying the pharmacokinetic (PK) profile and toxic effects. In this study, we evaluated the PK profile and cardiotoxicity of a new DOX ME (DOX‐ME). The PK profile of DOX‐ME was determined and compared with that of the conventional DOX after single‐dose administration (6 mg/kg, intravenous) in male Wistar rats (n = 12 per group). The cardiotoxicity of DOX formulations was evaluated by serum creatine kinase MB (CKMB) activity in both animal groups before and after drug administration. The plasma DOX measurements were performed by high‐performance liquid chromatography with fluorescence detection, and the CKMB levels were assayed using the CKMB Labtest® kit. The ME system showed a significant increase in plasma DOX concentrations and lower distribution volume when compared with conventional DOX. Serum CKMB activity increased after conventional DOX administration but was unchanged in the DOX‐ME group. These results demonstrate modifications in drug access to susceptible sites using DOX‐ME. DOX‐ME displayed features that make it a promising system for future therapeutic application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 1, January 2013, Pages 289-296
نویسندگان
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