کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485568 | 1114360 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Wormlike Micellar Aggregates of Saponins from Ilex paraguariensis A. St. Hil. (mate): A Characterisation by Cryo-TEM, Rheology, Light Scattering and Small-Angle Neutron Scattering
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Wormlike Micellar Aggregates of Saponins from Ilex paraguariensis A. St. Hil. (mate): A Characterisation by Cryo-TEM, Rheology, Light Scattering and Small-Angle Neutron Scattering Wormlike Micellar Aggregates of Saponins from Ilex paraguariensis A. St. Hil. (mate): A Characterisation by Cryo-TEM, Rheology, Light Scattering and Small-Angle Neutron Scattering](/preview/png/2485568.png)
چکیده انگلیسی
This work reports the physico-chemical characterisation of the micellar structures formed by a saponin fraction obtained from an important South American species, Ilex paraguariensis (mate). The mate saponin-enriched fraction (MSF) mainly comprises triterpenic glycosides and was obtained from mate green fruits through solid-phase extraction. The physico-chemical studies focused on the determination of the critical micellar concentration (CMC), the size and shape of the micelles, using conventional transmission electronic microscopy (TEM), as well as Cryo-TEM, light scattering and small-angle neutron scattering. The rheological behaviour of the solutions up to 4Â wt% was also determined using a controlled-strain rheometer. Finally, the MSF ability to solubilise poorly water-soluble drugs was assayed using carbamazepine and flurbiprofen as basic and weak acidic drug models. Small spherical micelles of around 20 Ã
radius were observed in the presence of elongated structures with lengths of more than 500Â nm, possessing a well-defined CMC of 0.41Â g/L. MSF solutions ranging from 0.25 to 4% (w/v) demonstrated a viscoelastic behaviour independent of the concentration. MSF could improve the solubility of carbamazepine in the range of 0.13 to 1.5% (w/v)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 2, February 2011, Pages 536-546
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 2, February 2011, Pages 536-546
نویسندگان
Maria Paula G. Peixoto, Janine Treter, Pedro Ernesto de Resende, Nádya Pesce da Silveira, George G. Ortega, M. Jayne Lawrence, Cécile A. Dreiss,