کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2485716 1114364 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PHARMACEUTICAL TECHNOLOGY: Micro-CT Analysis of Matrix-Type Drug Delivery Devices and Correlation With Protein Release Behaviour
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
PHARMACEUTICAL TECHNOLOGY: Micro-CT Analysis of Matrix-Type Drug Delivery Devices and Correlation With Protein Release Behaviour
چکیده انگلیسی
A series of matrix-type drug delivery devices comprising a continuous phase of microporous poly(ε-caprolactone) (PCL) and a dispersed phase of protein particles (gelatin) with defined size ranges (45-90, 90-125 and 125-250 μm) were produced by rapidly cooling suspensions in dry ice followed by solvent extraction from the hardened material. High protein loadings (38-44%, w/w) were achieved and highly efficient protein release (90% of the initial load) was obtained over time periods of 3-11 days depending on particle loading and size range. The duration of protein release was extended from 3 to 11 days reducing the protein load. Quantitative analysis of Micro-CT images identified a three to four times increase in the population of sub-40 mm pores in those matrices which gave rise to accelerated protein release in 24 h (40% rising to 80%) and reduced duration of protein release (11-3 days). Formation of a high density of channels and fissures (connects) between the particles is indicated, which facilitate fluid ingress and diffusion of solubilised protein molecules. Micro-CT analysis also confirmed the uniformity of particle distribution in the matrices and provided measurements of macroporosity within 530% of the theoretical value for materials displaying irregular shaped macropores larger than 90 mm. These findings demonstrate the utility of Micro-CT for optimising the formulation and performance of matrix-type delivery devices for macromolecular entities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 6, June 2010, Pages 2854-2862
نویسندگان
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