کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485850 | 1114368 | 2012 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decoupling the Eeffects of Esurface Chemistry and Humidity on Solid-State Hydrolysis of Aspirin in the Presence of Dicalcium Phosphate Dihydrate
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کلمات کلیدی
Drug interactions - تداخل داروییSolid state stability - ثبات حالت جامدMoisture sorption - جذب رطوبتSurface chemistry - شیمی سطحExcipients - عضلاتMaterials science - علم مواد یا دانش موادDegradation products - محصولات تخریب شدهatomic force microscopy - میکروسکوپ نیروی اتمیMicroscopy - میکروسکوپ یا ریزبینChemical stability - پایداری شیمیاییCrystals - کریستال ها
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Atomic force microscopy (AFM) cantilevers were functionalized with particles of dicalcium phosphate dihydrate (DCP), and AFM, in force-displacement mode, was used to bring these probes into contact with aspirin (100) and (001) surfaces in order to investigate the effect of aspirin surface chemistry on the interaction between the two materials as a function of relative humidity (RH). The force of adhesion measurements showed a strong dependence on RH for the interactions between DCP and the aspirin (100) surface, with stronger interactions occurring at higher humudities. Relatively much weaker interactions were measured between DCP and the aspirin (001) surface under all RH conditions. Topographic imaging showed that contact between DCP and the aspirin (100) surface at high RH led to localised development of etch pits and, in some cases, growth normal to the surface. The methodology allows for the creation of a localised solid-solid interface between pharmaceutically relevant materials, providing a means of studying solid-state excipient-active ingredient decomposition reactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 4, April 2012, Pages 1496-1507
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 4, April 2012, Pages 1496-1507
نویسندگان
Andrew M. Cassidy, Catherine E. Gardner, Tony Auffret, Barry Aldous, William Jones,