کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485858 | 1114368 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative In-Line Monitoring of Solvent-Mediated Polymorphic Transformation of Sulfamerazine by Near-Infrared Spectroscopy
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کلمات کلیدی
X-ray diffractometry (XRD)Principal component analysis (PCA) - آنالیز اجزا اصلیPartial least squares (PLS) - حداقل مربعات جزئی (PLS)Sulfamerazine - سولفام آمینNear-infrared spectroscopy (NIR) - طیف سنجی نزدیک به مادون قرمز (NIR)In-line monitoring - نظارت بر خطPolymorph - پلیمرورCalorimetry (DSC) - کالریمتری (DSC)
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The in-line monitoring of pharmaceutical processes with high risk, such as crystallization, has been one of the most popular research topics in recent years. Sulfamerazine (SMZ), a well-known sulfonamide antibacterial agent was investigated to examine the mechanism of polymorphic conversion by solvent-mediated polymorphic transformation (SMPT). The primary purpose of this study is to monitor the polymorphic transformation through in-line near-infrared (NIR) measurements and concurrently interpret the whole process quantitatively with off-line characterizations. Samples taken at every hour during SMPT were analyzed by X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). NIR spectra in the range of 7500-4900Â cmâ1 were taken into account for multivariate analysis, which included partial least square (PLS) regression and principal component analysis (PCA). In brief, the form II content was estimated very accurately and reproducibly during the SMPT process not only by XRD but also by the DSC measurements. In addition, the form II content values were predicted very accurately by separate experiments at two designated time points. In a separate study, it was demonstrated that PCA could be employed to explain a complicated process such as SMPT mechanistically by several stages
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 4, April 2012, Pages 1578-1586
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 4, April 2012, Pages 1578-1586
نویسندگان
Min-Jeong Lee, Da-Young Seo, In-Chun Wang, Nan-Hee Chun, Hea-Eun Lee, Myung-Yung Jeong, Woo-Sik Kim, Guang J. Choi,