کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485875 | 1114369 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Critical Assessment of Inverse Gas Chromatography as Means of Assessing Surface Free Energy and Acid-Base Interaction of Pharmaceutical Powders
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Critical Assessment of Inverse Gas Chromatography as Means of Assessing Surface Free Energy and Acid-Base Interaction of Pharmaceutical Powders Critical Assessment of Inverse Gas Chromatography as Means of Assessing Surface Free Energy and Acid-Base Interaction of Pharmaceutical Powders](/preview/png/2485875.png)
چکیده انگلیسی
Inverse gas chromatography (IGC) has been employed as a research tool for decades. Despite this record of use and proven utility in a variety of applications, the technique is not routinely used in pharmaceutical research. In other fields the technique has flourished. IGC is experimentally relatively straightforward, but analysis requires that certain theoretical assumptions are satisfied. The assumptions made to acquire some of the recently reported data are somewhat modified compared to initial reports. Most publications in the pharmaceutical literature have made use of a simplified equation for the determination of acid/base surface properties resulting in parameter values that are inconsistent with prior methods. In comparing the surface properties of different batches of αâlactose monohydrate, new data has been generated and compared with literature to allow critical analysis of the theoretical assumptions and their importance to the interpretation of the data. The commonly used (simplified) approach was compared with the more rigorous approach originally outlined in the surface chemistry literature. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2647-2654, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 10, October 2007, Pages 2647-2654
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 10, October 2007, Pages 2647-2654
نویسندگان
Martin J. Telko, Anthony J. Hickey,