Estimation of the ideal solubility (crystal-liquid fugacity ratio) of organic compounds

Melting point, entropy of melting and heat capacity of melting are required for the calculation of the ideal solubility of a solid solute via the Clausius-Clapyron equation. This article reviews the published approximations of estimating entropy and heat capacity of melting. By comparing the available experimental results to calculated values the authors attempt to identify the best estimation of the ideal solubility and crystal-liquid fugacity ratio for organic compounds. © 2009 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1100-1106, 2010