کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486178 | 1114377 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices](/preview/png/2486178.png)
چکیده انگلیسی
This paper describes the evaluation of a new pharmaceutical formulation based on ketoprofen entrapment in a solid lipid particle (SLP) matrix. The drug-SLP samples, which were elaborated using a processing technology based on supercritical CO2, consisted of a model of a controlledârelease system for topical applications. Some of the samples contained silanized TiO2 as an additional ingredient to increase the interaction between drug and lipid matrix. The study of the sample features relied on reversedâphase highâperformance liquid chromatography with a C18 column and ultraviolet spectroscopic detection at 266ânm. Characterization assays comprised the determination of the overall amount of ketoprofen in the samples, the assessment of the release-permeation kinetic profiles, and the evaluation of impurities and decomposition products. The release and permeation of encapsulated ketoprofen were assayed at 32°C and pH 6.8 by using a static diffusion cell. Results showed a sustained drug delivery for at least 24âh. Besides, no degradation species were detected throughout the release-permeation processes, which indicated that the stability of the drug in the SLP system was preserved. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:4783-4789, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 11, November 2011, Pages 4783-4789
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 11, November 2011, Pages 4783-4789
نویسندگان
Anna ArgemÃ, Concepción Domingo, Ana Raquel Sampaio de Sousa, Catarina M. M. Duarte, Carlos A. GarcÃaâgonzález, Javier Saurina,