کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486183 | 1114377 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water](/preview/png/2486183.png)
چکیده انگلیسی
Sodium deoxycholate (NaDC) is an important example of bile salts, representing systems with complex phase behavior involving both crystalline and mesophase structures. In this study, properties of NaDC-water mixtures were evaluated as a function of composition and temperature via Xâray diffraction with synchrotron (sXRD) and laboratory radiation sources, water sorption, polarized light, hotâstage microscopy, and freezingâpoint osmometry. Several phases were detected depending on the composition and temperature, including isotropic solution phase, liquid crystalline (LC) phase, crystalline hydrate, and ice. The LC phase was identified as hexagonal structure by sXRD, with up to 14 highâorder reflections detected. The crystalline phase was found to be nonstoichiometric hydrate, based on XRD and water sorption data. The phase diagram of NaDC-water system has been refined based on both results of this study and other reports in literature. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:4836-4844, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 11, November 2011, Pages 4836-4844
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 11, November 2011, Pages 4836-4844
نویسندگان
Ziyang Su, Suman Luthra, Joseph F. Krzyzaniak, Dena M. AgraâKooijman, Satyendra Kumar, Stephen R. Byrn, Evgenyi Y. Shalaev,