کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486311 | 1114380 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation, characterization, and drug release in vitro of chitosan-glycyrrhetic acid nanoparticles
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کلمات کلیدی
In vitro release - آزمایشی in vitroGlycyrrhetic acid - اسید گلیسیررتیکEncapsulation efficiency - بازده انعقادیBiocompatibility - زیست سازگاریFTIR - طیف سنج مادون قرمزFluorescence spectroscopy - فوتولومینسانس یا فلوئورسانس یا فسفرسانسMicroscopy - میکروسکوپ یا ریزبینNanoparticles - نانوذراتLight-scattering - پراکندگی نورChitosan - کیتوسان
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation, characterization, and drug release in vitro of chitosan-glycyrrhetic acid nanoparticles Preparation, characterization, and drug release in vitro of chitosan-glycyrrhetic acid nanoparticles](/preview/png/2486311.png)
چکیده انگلیسی
A suitable carrier chitosan (CS) was used to prepare CS-Glycyrrhetic acid (GLA) nanoparticles under very mild conditions by polyelectrolyte complexation. These nanoparticles were well dispersed and stable in aqueous solution, and the physicochemical properties of which were investigated by FT-IR, dynamic light scattering, transmission electron microscope, fluorescence spectra and zeta potential. It was found that only when the weight ratio of CS to GLA was lower than 16.7, could the nanoparticles be formed. The prepared nanoparticles carried a positive charge and had the dried TEM-assessed size in the range from 20 to 30Â nm. The mean hydrated diameter, size distribution and zeta potential of the nanoparticles could be controlled by some factors including the weight ratio of CS to GLA, the average molecular weight of CS and the pH value of the medium. It was also found that GLA encapsulation efficiency into the nanoparticles increased with the increase of the weight ratio of CS to GLA. The experiment of GLA release in vitro showed that the effect of CS encapsulation on GLA release was obvious and the CS-GLA nanoparticles system might be used to provide a continuous release. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 1, January 2006, Pages 181-191
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 1, January 2006, Pages 181-191
نویسندگان
Yongli Zheng, Yan Wu, Wuli Yang, Changchun Wang, Shoukuan Fu, Xizhong Shen,