کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486357 | 1114381 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: Influence of pressure on the structure and drug release
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: Influence of pressure on the structure and drug release Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: Influence of pressure on the structure and drug release](/preview/png/2486357.png)
چکیده انگلیسی
Ordered mesoporous silica (OMS) materials are considered a promising drug delivery system for the dissolution enhancement of poorly soluble compounds. The purpose of the present work was to determine structural and behavioral changes of compressed OMS material necessary for the development of an immediateârelease oralâdosage formulation. Two types of OMS materials (SBAâ15 and COKâ12) were subjected to pressures both in and beyond the tabletting region and characterized by nitrogen physisorption, scanning and transmission electron microscopy, smallâangle Xâray scattering, and differential scanning calorimetry. Itraconazole was used as the poorly soluble model drug and the release process with respect to pressure was determined in vitro. The resulting decreased drug release due to increased pressure was recovered by incorporating a plastically deforming material such as microcrystalline cellulose in combination with croscarmellose sodium. These findings further elucidate the understanding of their structural behavior for the advancement as a drug delivery carrier. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:3411-3420, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 8, August 2011, Pages 3411-3420
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 8, August 2011, Pages 3411-3420
نویسندگان
Monica Vialpando, Alexander Aerts, Jeroen Persoons, Johan Martens, Guy Van Den Mooter,