کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486493 | 1114384 | 2010 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanistic insight into the dermal delivery from nanoparticle-coated submicron O/W emulsions
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mechanistic insight into the dermal delivery from nanoparticle-coated submicron O/W emulsions Mechanistic insight into the dermal delivery from nanoparticle-coated submicron O/W emulsions](/preview/png/2486493.png)
چکیده انگلیسی
The influence of silica nanoparticle coating of negatively and positively charged submicron emulsion oil droplets on the dermal delivery of a lipophilic fluorescent probe, acridine orange 10-nonyl bromide (AONB) using an ex vivo porcine skin model is reported. The skin retention and depth of the penetration of AONB significantly increased (pââ¤â0.05) up to a skin depth of â¼265âµm by nanoparticle coating of negative lecithin-stabilised emulsion oil droplets especially when nanoparticles were added from the water phase. The extent and depth of penetration of AONB incorporated into positively charged silica-coated oleylamine-stabilised emulsions significantly increased up to the upper dermis (â¼290âµm) with more pronounced effect by nanoparticle incorporation from the water phase of the control oleylamine emulsion. The permeation of AONB through full-thickness porcine skin was negligible (<0.12% of the topically applied dose). The skin penetration profile of AONB was well correlated to the more facilitated transport of the electrostatically bond silica-AONB complex compared to free AONB as one of the potential mechanisms of the improved delivery. The skin permeation of silica nanoparticles was negligible (<1âµgâmLâ1 after a 6-h exposure time) which demonstrated the potential of nanoparticle-coated emulsions for topical targeting. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:890-904, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 2, February 2010, Pages 890-904
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 2, February 2010, Pages 890-904
نویسندگان
Nasrin Ghouchi Eskandar, Spomenka Simovic, Clive A. Prestidge,