کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486497 | 1114384 | 2010 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dielectric properties of pharmaceutical materials relevant to microwave processing: Effects of field frequency, material density, and moisture content
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The rising popularity of microwaves for drying, material processing and quality sensing has fuelled the need for knowledge concerning dielectric properties of common pharmaceutical materials. This article represents one of the few reports on the density and moisture content dependence of the dielectric properties of primary pharmaceutical materials and their relevance to microwave-assisted processing. Dielectric constants (εâ²) and losses (εâ³) of 13 pharmaceutical materials were measured over a frequency range of 1âMHz-1âGHz at 23â±â1°C using a parallel-electrode measurement system. Effects of field frequency, material density and moisture content on dielectric properties were studied. Material dielectric properties varied considerably with frequency. At microwave frequencies, linear relationships were established between cube-root functions of the dielectric parameters (εâ²3 and εâ³3) and density which enabled dielectric properties of materials at various densities to be estimated by regression. Moisture content was the main factor that contributed to the disparities in dielectric properties and heating capabilities of the materials in a laboratory microwave oven. The effectiveness of a single frequency density-independent dielectric function for moisture sensing applications was explored and found to be suitable within low ranges of moisture contents for a model material. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:941-957, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 2, February 2010, Pages 941-957
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 2, February 2010, Pages 941-957
نویسندگان
Paul W.S. Heng, Z.H. Loh, Celine V. Liew, C.C. Lee,