Study on the Interactions Between Polyvinylpyrrolidone (PVP) and Acetaminophen Crystals: Partial Dissolution Pattern Change

The objective of the study was to investigate the interactions between polyvinylpyrrolidone (PVP) and acetaminophen crystal especially on crystal surface. The effects of PVP on the etching pattern change of the acetaminophen (010) face, solubility enhancement as well as the intrinsic dissolution rate (IDR) of acetaminophen crystals have been studied. The etching patterns of the acetaminophen (010) face in the presence of PVP have stable ledges in the direction of a-axis, but deviate from c-axis, which shows that the dissolution on the (010) face has been affected by the adsorbed PVP especially in the direction of c-axis through van der Waals interactions rather than hydrogen bonding interactions. Even though PVP(K30) can enhance the solubility of acetaminophen in concentration higher than 1 mg/mL, the IDR of acetaminophen in diluted PVP solutions was lower than in water. Because the viscosity of those diluted PVP(K30) solutions were the same as water viscosity, the lowered IDR of acetaminophen cannot be explained simply by the viscosity effects of PVP solutions. Overall, the study suggests that the PVP molecules adsorbed on the surface of acetaminophen crystals play an important role in etching pattern change as well as the intrinsic dissolution rate change. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association