Iontophoretic Transdermal Delivery of Sumatriptan: Effect of Current Density and Ionic Strength

Iontophoretic transdermal delivery of sumatriptan was investigated in vitro. Among the conditions tested, 0.25 mA/cm2 and low ionic strength (NaCl 25 mM) was the best experimental condition to increase its transport across the skin. The flux increased 385-fold respective to passive diffusion, thus resulting in a transdermal flux of sumatriptan of 1273 ± 83 nmol/cm2 h. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association