کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486542 | 1114386 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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![عکس صفحه اول مقاله: Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration](/preview/png/2486542.png)
چکیده انگلیسی
The study investigates the influence of surface charge, generation and concentration of poly(amidoamine) (PAMAM) dendrimers on skin permeation of a model hydrophilic drug, 5-fluorouracil (5FU). Permeation studies were performed using excised porcine skin in a Franz diffusion cell. Saturated concentration of 5FU in isopropyl myristate was applied on the skin after pretreatment with dendrimers and 14C labeled 5FU was analyzed using a liquid scintillation counter. The influence of dendrimer surface charge (G4-NH2, G3.5-COOH, and G4-OH), generations (G2-G6-NH2) and concentration (0.1-10Â mM of G4-NH2) on skin permeation of 5FU were studied. The enhancement in drug permeability coefficient (Kp) was in the following decreasing order G4-NH2Â >Â G4-OHÂ >Â G3.5-COOH. Dendrimer increased the skin permeation by increasing the skin partitioning of 5FU. Transepidermal water loss, skin resistance measurements and ATR-FTIR studies revealed that cationic dendrimers act by interacting with the skin lipid bilayers. Increase in G4-NH2 concentration did not proportionally increase the skin permeation of 5FU. The 5FU Kp was inversely related to the molecular weight of the dendrimer. G2-NH2 dendrimer reduced skin resistance to a greater extent than higher generation dendrimers. Overall, the study showed that lower generation cationic dendrimer is more effective in enhancing the skin permeation of hydrophilic drugs. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 7, July 2009, Pages 2345-2356
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 7, July 2009, Pages 2345-2356
نویسندگان
Venkata Vamsi K. Venuganti, Omathanu P. Perumal,