کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486703 | 1114391 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physical Characterization of Dibasic Calcium Phosphate Dihydrate and Anhydrate
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کلمات کلیدی
dibasic calcium phosphateWater in solids - آب در جامداتAmorphous - آمورفThermal analysis - آنالیز حرارتیX-ray diffractometry - اشعه ماوراء بنفشParticle size - اندازه ذراتPhysical stability - ثبات فیزیکیPhysical characterization - خصوصیات فیزیکیDehydration - دهیدراسیون، کمآبی بدنCalorimetry (DSC) - کالریمتری (DSC)
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Physical Characterization of Dibasic Calcium Phosphate Dihydrate and Anhydrate Physical Characterization of Dibasic Calcium Phosphate Dihydrate and Anhydrate](/preview/png/2486703.png)
چکیده انگلیسی
The dehydration of different commercial brands of dibasic calcium phosphate dihydrate (DCPD; CaHPO4·2H2O) was examined over a range of temperatures and water vapor pressures. To determine the main factors affecting the physical stability of DCPD, the baseline characterization of DCPD and dibasic calcium phosphate anhydrate (DCPA; CaHPO4) was conducted by thermogravimetric analysis, differential scanning calorimetry and X-ray diffractometry. The surface area and the DCPA content (present as an impurity) depended on the commercial source of DCPD. The larger particles contained a higher concentration of DCPA and the anhydrate exhibited a concentration-dependent acceleratory effect on the dehydration of DCPD. Unlike DCPD, DCPA is physically stable and resisted hydration even when dispersed in water for over 7 months in the temperature range of 4-50°C. In dosage forms containing DCPD, there is a potential for phase transformation to DCPA, while the reverse transition, that is, DCPA â DCPD appears to be extremely unlikely. Thus, the risk of physical transformation can be minimized by using DCPA in formulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 3, March 2009, Pages 905-916
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 3, March 2009, Pages 905-916
نویسندگان
Tamaki Miyazaki, Kannan Sivaprakasam, Jaidev Tantry, Raj Suryanarayanan,