کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486847 1114395 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-Invasive Product Temperature Determination during Primary Drying using Tunable Diode Laser Absorption Spectroscopy
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Non-Invasive Product Temperature Determination during Primary Drying using Tunable Diode Laser Absorption Spectroscopy
چکیده انگلیسی

ABSTRACTThe goal of this work was to demonstrate the application of Tunable Diode Laser Absorption Spectroscopy (TDLAS) as a non-invasive method to determine the average product temperature of the batch during primary drying. The TDLAS sensor continuously measures the water vapor concentration and the vapor flow velocity in the spool connecting the freeze-dryer chamber and condenser. Vapor concentration and velocity data were then used to determine the average sublimation rate (g/s) which was subsequently integrated to evaluate the amount of water removed from the product. Position dependent vial heat transfer coefficients (Kv) were evaluated using the TDLAS sensor data for 20 mL vials during sublimation tests with pure water. TDLAS Kv data showed good agreement to Kv data obtained by the traditional gravimetric procedure. Kv for edge vials was found to be about 20–30% higher than that of center vials. A weighted Kv was then used to predict a representative average product temperature from TDLAS data in partial and full load freeze drying runs with 5%, 7.5%, or 10% (w/w) sucrose, mannitol, and glycine solutions. TDLAS product temperatures for all freeze-drying runs were within 1–2 °C of "center vial'' steady state thermocouple data. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3406–3418, 2009

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 9, September 2009, Pages 3406–3418
نویسندگان
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