کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486896 1114397 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transforming Powder Mechanical Properties by Core/Shell Structure: Compressible Sand
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Transforming Powder Mechanical Properties by Core/Shell Structure: Compressible Sand
چکیده انگلیسی
Some active pharmaceutical ingredients possess poor mechanical properties and are not suitable for tableting. Using fine sand (silicon dioxide), we show that a core/shell structure, where a core particle (sand) is coated with a thin layer of polyvinylpyrrolidone (PVP), can profoundly improve powder compaction properties. Sand coated with 5% PVP could be compressed into intact tablets. Under a given compaction pressure, tablet tensile strength increases dramatically with the amount of coating. This is in sharp contrast to poor compaction properties of physical mixtures, where intact tablets cannot be made when PVP content is 20% or less. The profoundly improved tabletability of core/shell particles is attributed to the formation of a continuous three-dimensional bonding network in the tablet.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 11, November 2010, Pages 4458-4462
نویسندگان
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