کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486910 1114397 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of Amphotericin B With Cholesteryl Palmityl Carbonate Ester
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Interaction of Amphotericin B With Cholesteryl Palmityl Carbonate Ester
چکیده انگلیسی
A cholesteryl carbonate ester was prepared and evaluated as a possible thermotropic liquid crystal excipient for dry powder inhalers. Cholesteryl palmityl carbonate (CPC) was synthesized, and the phase behavior was characterized by differential scanning calorimetry, transmission electron microscopy, polarized light microscope, small angle X-ray diffraction, and solid-state nuclear magnetic resonance spectroscopy. Amphotericin B (AmB) was incorporated into CPC at various mole% (7.7, 14.3, 25, 33.3, and 50) using a solvent evaporation method. The amount of AmB loaded into liquid crystal was limited. The mixture of AmB in liquid crystal did not produce a new complex; rather, the addition of AmB affected the orientational order and the motional aspects of liquid crystal molecules. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:4593-4602, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 11, November 2010, Pages 4593-4602
نویسندگان
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