کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487073 1114402 2010 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the Use of a Dual-Scale Model to Improve Understanding of a Pharmaceutical Freeze-Drying Process
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
On the Use of a Dual-Scale Model to Improve Understanding of a Pharmaceutical Freeze-Drying Process
چکیده انگلیسی
The evolution of product temperature and of residual ice content in the various vials of a batch during a freeze-drying process can be significantly affected by local conditions around each vial. In fact, vapor fluid dynamics in the drying chamber determines the local pressure that, taking into account the heat flow from the shelf and, eventually, radiation from chamber surfaces, is responsible for the sublimation rate and product temperature. These issues have to be taken into account when using mathematical simulation to predict the evolution of the product as a consequence of the operating conditions (recipe design), as well as during the scale-up of a recipe obtained in a small-scale equipment to a large-scale unit. In this framework, a dual-scale model can significantly improve the understanding for pharmaceuticals freeze-drying processes: it couples a three-dimensional model, describing the fluid dynamics in the chamber, and a second mathematical model, either mono- or bi-dimensional, describing the drying of the product in each vial. Thus, it can be profitably used to gain knowledge about process dynamics, and to improve the design of the equipment, as well as the performance of the control system of the process. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:4337-4350,
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 10, October 2010, Pages 4337-4350
نویسندگان
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