کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487102 | 1114403 | 2009 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydrodynamic, mass transfer, and dissolution effects induced by tablet location during dissolution testing
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Tablets undergoing dissolution in the USP Dissolution Testing Apparatus II are often found at locations on the vessel bottom that are off-center with respect to the dissolution vessel and impeller. A previously validated CFD approach and a novel experimental method were used here to examine the effect of tablet location on strain rates and dissolution rates. Dissolution tests were conducted with nonâdisintegrating tablets (salicylic acid) and disintegrating tablets (Prednisone) immobilized at different locations along the vessel bottom. CFD was used to predict the velocity profiles and strain rates when the tablets were placed at such locations. A CFDâbased model was derived to predict the mass transfer coefficient and dissolution curves, which were then compared to the experimental results. Both nonâdisintegrating and disintegrating offâcenter tablets experimentally produced higher dissolution rates than centered tablets. The CFDâpredicted strain rate distribution along the bottom was highly not uniform and the predicted strain rates correlated well with the experimental mass transfer coefficients. The proposed CFDâbased model predicts mass transfer rates that correlate well with the experimental ones. The exact tablet location has a significant impact on the dissolution profile. The proposed model can satisfactorily predict the mass transfer coefficients and dissolution profiles for nonâdisintegrating tablets. © 2008 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 98:1511-1531, 2009
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 4, April 2009, Pages 1511-1531
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 4, April 2009, Pages 1511-1531
نویسندگان
Ge Bai, Piero M. Armenante,