کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487119 | 1114405 | 2009 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fighting Cancer: From the Bench to Bedside Using Second Generation Cationic Liposomal Therapeutics
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The use of second generation cationic liposomes to deliver cytotoxic drugs to solid tumors is a rational and promising therapeutic approach, given the natural affinity of cationic carrier molecules for the tumor microvasculature. Cationic liposomal therapeutics are effective in the treatment of cancers that are resistant to conventional chemotherapy and other treatment modalities. Researchers are now exploring novel ways to combine cationic nanosystems with other treatment approaches. For example, strategies for using cationic liposomes with hyperthermia or magnetic fields have been evaluated. Drugâloaded cationic liposomes have been documented to induce tumor vascular defects, alter vascular function and limit the growth of the primary tumors and metastasis. In this review, we discuss general features of the endothelium as a function of its tissue environment. We discuss the rationale for targeting tumor vessels over the tumor interstitial matrix, and for the development of second generation cationic lipids and liposomes for tumor vascular targeting. We evaluate the benefits of incorporating the polymer polyethyleneâglycol (PEG) in conventional and cationic liposomes for nonspecific and relatively vascularâspecific tumor targeting, respectively. Finally, we review preclinical and clinical investigations evaluating drugâloaded cationic liposomes in cancer treatment. © 2008 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 98:411-429, 2009
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 2, February 2009, Pages 411-429
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 2, February 2009, Pages 411-429
نویسندگان
Robert B. Campbell, Bo Ying, Geoffrey M. Kuesters, Ryan Hemphill,