کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487474 1114418 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the role of granule yield strength for the compactibility of granular solids
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
On the role of granule yield strength for the compactibility of granular solids
چکیده انگلیسی
The objective of this article was to explore the relationship between mechanical properties of single granules and the evolution in tensile strength and tablet micro‐structure. Granules of different expected deformation behavior were used as model materials. It is suggested that the role of plasticity in this context is twofold: firstly, to affect the rate of compactibility and thus the pressure range needed to reach the maximal attained tablet strength and, secondly, to affect the mode of deformation of the granules and thus the maximal attained tablet strength. A decrease in yield pressure of single granules increased the tablet tensile strength at a given compaction pressure. The yield pressure can be controlled by the granule composition and porosity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 11, November 2008, Pages 4807-4814
نویسندگان
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