کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487484 1114418 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of screw elements on continuous granulation with a twin-screw extruder
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Impact of screw elements on continuous granulation with a twin-screw extruder
چکیده انگلیسی
The influence of different screw element types on wet granulation process with a twin‐screw extruder was investigated. Lactose granules were prepared with different screw configurations such as conveying, combing mixer and kneading elements. The use of kneading blocks led to an almost complete agglomeration of lactose, whereas kneading and combing mixer elements resulted in smaller granules in comparison. Granule porosity varied between 17.4% and 50.6%. Granule friability values ranged from 1.2% to 38.5%. Conveying elements led to the most porous and friable granules, whereas kneading blocks produced the densest and least friable granules. Combing mixer elements produced granules with median properties. A linear correlation between granule porosity and the natural logarithm of granule friability was detected. Flowability of granules was also influenced by the element type. Compressed granules with higher granule porosities resulted in tablets with higher tensile strength values and vice versa. Twin‐screw extruders proved to be a versatile tool for wet granulation. By the choice of a suitable screw element granule and tablet characteristics were influenced. © 2008 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:4934-4942, 2008
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 11, November 2008, Pages 4934-4942
نویسندگان
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