کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487563 | 1114422 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oiling out or molten hydrate-liquid-liquid phase separation in the system vanillin-water
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Vanillin crystals in a saturated aqueous solution disappear and a second liquid phase emerges when the temperature is raised above 51°C. The phenomenon has been investigated with crystallization and equilibration experiments, using DSC, TGA, XRD and hotâstage microscopy for analysis. The new liquid solidifies on cooling, appears to melt at 51°C, and has a composition corresponding to a dihydrate. However, no solid hydrate can be detected by XRD, and it is shown that the true explanation is that a liquid-liquid phase separation occurs above 51°C where the vanillinârich phase has a composition close to a dihydrate. To our knowledge, liquid-liquid phase separation has not previously been reported for the system vanillin-water, even though thousands of tonnes of vanillin are produced globally every year. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2390-2398, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2390-2398
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2390-2398
نویسندگان
Michael Svärd, Sandra Gracin, Ã
ke C. Rasmuson,