کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487569 1114422 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization and Selective Crystallization of Famotidine Polymorphs
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Characterization and Selective Crystallization of Famotidine Polymorphs
چکیده انگلیسی
Famotidine crystallizes in two different polymorphic forms: the metastable polymorph B and the stable polymorph A. In this work, solid characterization for both polymorphs has been conducted in detail. The solubility, metastable zone width and interfacial energy of both polymorphs in different solvents have been measured. The influence of solvent, cooling rate, initial concentration and the temperature of nucleation on polymorphism has been investigated. Results show that the nature of polymorph that crystallizes from solution depends on the initial concentration of the solution, solvent, cooling rate, and the temperature of nucleation. Polymorph B preferentially crystallizes only at high concentrations. When acetonitrile or methanol is used as solvent, cooling rate can affect the polymorph of product only at high concentrations. While water is used as solvent, cooling rate has no effect on the polymorph of product, and nucleation temperature is found to be the predominant controlling factor. The effect of crystallization conditions on the polymorph of famotidine can be mainly attributed to the conformational polymorphism. Finally the “polymorphic window” for famotidine crystallized from aqueous solution has been described. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2457-2468, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 9, September 2007, Pages 2457-2468
نویسندگان
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