کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487631 | 1114424 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural characterization of anhydrous naloxoneâ and naltrexone hydrochloride by high resolution laboratory Xâray powder diffraction and thermal analysis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural characterization of anhydrous naloxoneâ and naltrexone hydrochloride by high resolution laboratory Xâray powder diffraction and thermal analysis Structural characterization of anhydrous naloxoneâ and naltrexone hydrochloride by high resolution laboratory Xâray powder diffraction and thermal analysis](/preview/png/2487631.png)
چکیده انگلیسی
The crystal structures of the analgesic compounds anhydrous naloxone and naltrexone hydrochloride were determined ab initio from high resolution laboratory Xâray powder diffraction data. Both compounds crystallize in the orthorhombic space group P212121 with lattice parameters of a = 14.6588(10) Ã
, b = 17.4363(9) Ã
, c = 7.96200(22) Ã
, and V = 2035.06(23) Ã
3 for naloxone hydrochloride and a = 15.4560(5) Ã
, b = 14.9809(4) Ã
, c = 7.84121(18) Ã
, and V = 1815.58(11) Ã
3 for naltrexone hydrochloride. The crystal structure of anhydrous naloxone hydrochloride forms oneâdimensional chains through hydrogen bonds. In the crystal structure of anhydrous naltrexone hydrochloride, twoâdimensional sheets are formed by hydrogen bonds. The dehydration processes of naloxone hydrochloride dehydrate and naltrexone hydrochloride tetrahydrate was analyzed by DTA, DSC, TG, and MG. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 3316-3323, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 12, December 2007, Pages 3316-3323
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 12, December 2007, Pages 3316-3323
نویسندگان
Kunihisa Sugimoto, Robert E. Dinnebier, Marek Zakrzewski,