Solid state characterization of progesterone in a freeze dried 1:2 progesterone/HPBCD mixture

Progesterone rapidly dissolves in an aqueous solution containing hydroxypropyl‐β‐cyclodextrin (HPBCD) at 1:2 molar ratio, forming a soluble inclusion complex. After filtration and freeze‐drying of the final solution, the final powder was examined by SEM, DSC, TGA, XRD, Raman, and FTIR spectroscopy. Experimental results confirm that an inclusion complex exists in the solid state and possible structure of the complex is briefly discussed. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1729-1736, 2007