کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2487678 1114428 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PHARMACEUTICS, PREFORMULATION ANDDRUG DELIVERY : Relationships between Structural and Thermal Properties of Anhydrous and Solvated Crystalline Forms of Brodimoprim
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
PHARMACEUTICS, PREFORMULATION ANDDRUG DELIVERY : Relationships between Structural and Thermal Properties of Anhydrous and Solvated Crystalline Forms of Brodimoprim
چکیده انگلیسی

ABSTRACTThe isolation and physicochemical characterization of four crystalline modifications of brodimoprim (5-[(4-bromo-3,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine, hereinafter BMP), a structural analog of trimethoprim (TMP), are reported. These phases include an unsolvated form of BMP, a hemihydrate (BMP·0.5H2O), a 1:1 solvate containing isopropanol (BMP·C3H7OH(iso)), and a hemichloroformate (BMP·0.5CHCl3). Unsolvated BMP was isolated both by recrystallization from a range of common solvents as well as by thermal decomposition of the above solvates and no evidence for polymorphism was found. PXRD data indicated that the three solvates crystallize in different arrangements. Data from thermal analysis (thermogravimetry (TGA), hot stage microscopy (HSM), differential scanning calorimetry (DSC)) of the solvates containing water and iso-propanol were interpreted on the basis of their single-crystal X-ray structures which revealed that the modes of solvent inclusion in BMP·0.5H2O and BMP·C3H7OH(iso) may be described as ‘isolated site’ and ‘lattice channel’ type inclusions, respectively. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 996–1007, 2007

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 5, May 2007, Pages 996–1007
نویسندگان
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